Swertia chirayita

100 and 200 mg/kg,

orally

Female swiss albino mice,

paracetamol-induced hepatotoxicity

Due to free radical scavenging activity

Nagalekshmi et al.

(2011)

Taraxacum

officinale

500 mg/kg, i.p.

Male Wistar rats, sodium dichromate-

induced liver injury

Due to the antioxidant properties of the

phytochemical constituents present in the

extract

Hfaiedh et al. (2016)

Terminalia arjuna

1, 5, 10, 25, 50 mg

and 100 mg/kg, orally

Swiss albino mice, CCl4-induced

hepatotoxicity

The extract exhibits potent antioxidant

activity, thereby protects the liver and

kidney via alteration of cytochrome P450

Manna et al. (2006)

Tragopogon

porrifolius

50 and 250 mg/kg, i.

p.

Male Wistar rats, CCl4-induced

hepatotoxicity

Due to the antioxidant activity of high

contents of phenols and flavonoids present

in the extract

Tenkerian et al.

(2015)

Cleome viscosa

(Cliv-92)

100 and 200 mg/kg,

orally

Albino rats (Druckrey strain), CCl4-

induced hepatotoxicity

Might be due to the interference of

compounds with cytochrome P450, which

results in the interference in the formation

of free radicals and thereby protecting the

integrity of the membranes

Gupta and Dixit

(2009)

Oleanolic acid

20, 40, 80 mg/kg, s.c.

Male Balb/c mice, concanavalin

A-induced liver damage

Through the activation of PPARα,

inhibiting the apoptosis and autophagy

through inhibition of JNK signalling

Wang et al. (2018)

Ursolic acid

5, 10, 20 mg/kg,

orally

Druckrey rats, paracetamol-induced

hepatotoxicity

May be due to its stabilizing effect on

plasma membrane

Shukla et al. (1992)

Berberine

80, 120 and 160 mg/

kg, orally

Male Sprague-Dawley rats, CCl4-

induced hepatotoxicity

Preventive and curative effects of

berberine

Feng et al. (2010)

Naringenin

50 mg/kg, orally

Swiss male mice, CCl4-induced

hepatotoxicity

Due to its ability to scavenge free radicals

Hermenean et al.

(2014)

Proanthocyanidins

10 and 50 mg/kg,

orally;

100 mg/kg, orally

Male Sprague-Dawley rats, ethanol-

induced hepatotoxicity

Male Wistar rats, cadmium-induced

hepatotoxicity

By directly scavenging ROS, regulating

ADH and ALDH enzymes and inhibiting

CYP2E1 expression;

Increase the aerobic capacity of muscle

tissue and improve the mitochondrial

function

Miltonprabu and

Manoharan (2016),

Bak et al. (2016)

(continued)

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